A. Passive and active targeting of NPs to cancer cells. Bookshelf 35, 975979. (2019). (2019). sharing sensitive information, make sure youre on a federal Lett. Cancer 10, 922. Nat. government site. doi: 10.1096/fj.12-218081, Park, H., Yang, J., Lee, J., Haam, S., Choi, I. H., and Yoo, K. H. (2009). doi: 10.1039/c6nr08486a, Zhang, J., Wang, L., You, X., Xian, T., Wu, J., and Pang, J. | Moreover, matrix metalloproteinase (MMP), a component of the tumor microenvironment, is engaged in extracellular matrix remodeling and tumor neovascularization (Lia et al., 2009). Furthermore, NPs, such as polymers, also act as MDR modulators (Qin et al., 2018). doi: 10.1002/adma.201703740, Li, W., Zhang, H., Assaraf, Y. G., Zhao, K., Xu, X., Xie, J., et al. Biol. Nanomed. Rep. 6:35267. doi: 10.1038/srep35267, Zhou, Q., Zhang, L., Yang, T., and Wu, H. (2018). Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment. Nanotechnology improves cancer detection and, Nanotechnology improves cancer detection and diagnosis, Schematic illustration of nanotechnology applications, Schematic illustration of nanotechnology applications in cancer diagnosis, MeSH The advantages initiate by means of the fundamental effects of nanotechnology and the biological difficulties it can overcome. Risk perception and weighing up the risks and benefits. EGFR and cancer prognosis. 2022;12(6):515-531. doi: 10.34172/bi.2022.23433. Litman, T., Brangi, M., Hudson, E., Fetsch, P., Abati, A., Ross, D. D., et al. MMP-sensitive NPs have been reported to play a potential antitumor effect in several types of cancers, including breast cancer, pancreatic cancer, and melanoma (Mansour et al., 2003; Xiao et al., 2018; Cun et al., 2019). Unauthorized use of these marks is strictly prohibited. doi: 10.1016/j.actbio.2015.09.032, Hua, S., and Wu, S. Y. Visentin S, Sedi M, Paveli SK, Paveli K. Curr Med Chem. Numerous studies have been carried out to explore the targeting design of NP-based drugs. A 106, 32033210. Several studies have reported the effectiveness of nanosystems containing HIF-1 siRNA to overcome drug resistance in cancer (Zhao et al., 2015; Luan et al., 2018; Hajizadeh et al., 2020). Several applications of ozonation were examined in this study for: i. the treatment of stabilized high strength municipal landfill leachates, ii. doi: 10.1021/ar200054n, Siegel, R. L., Miller, K. D., and Jemal, A. To present potential targets and new strategies for curbing the occurrence of ovarian metastasis and the treatment of ovarian cancer after metastasis, the first section of this paper explained the metastatic mechanisms of ovarian cancer comprehensively. doi: 10.1080/1061186x.2017.1379525, Reddy, K. R., Guan, Y., Qin, G., Zhou, Z., and Jing, N. (2011). doi: 10.1016/j.jare.2019.02.036, Legge, C. J., Colley, H. E., Lawson, M. A., and Rawlings, A. E. (2019). Theranostics 9, 60026018. Meanwhile, this system can be effectively internalized by cancer cells (Su et al., 2013) and avoids fast clearance by the reticuloendothelial system (Hu et al., 2015). Targeted magnetic nanoparticle hyperthermia for the treatment of oral cancer. Surface modification of liposomes by a lipopolymer targeting prostate specific membrane antigen for theranostic delivery in prostate cancer. Angiogenesis in cancer and other diseases. This cuts off the blood supply to the cancer cells, thus destroying the tumor. 1 It's Precise Appl. Drug Discov. Overexpression of VCAM-1 can be observed in various cancers (Dienst et al., 2005), indicating its potential role in the active targeting of NPs for drug delivery. Materials 12:2889. doi: 10.3390/ma12182889, Colapicchioni, V., Palchetti, S., Pozzi, D., Marini, E. S., Riccioli, A., Ziparo, E., et al. A new approach for the treatment of malignant melanoma: enhanced antitumor efficacy of an albumin-binding doxorubicin prodrug that is cleaved by matrix metalloproteinase 2. | Eur. Transferrin-conjugated polymeric nanoparticle for receptor-mediated delivery of doxorubicin in Doxorubicin-resistant breast cancer cells. Consequently, searching and developing more efficient and safer cancer treatment regimens are undoubted of great research value and clinical benefits. Int. Nanobiotechnol. In the meantime, to ensure continued support, we are displaying the site without styles Cancer nanotechnology: application of nanotechnology in cancer therapy. 27, 1429. 115, 243256. (2017). A recent study revealed the effectiveness of overcoming drug resistance in lung cancer therapy by combining miRNA-495 and doxorubicin into a cancer cell membrane-coated silica nanoparticle, results of which indicated that miR-495 effectively down-regulated P-gp expression in multidrug-resistant cancer cells (He et al., 2019). doi: 10.1016/j.biomaterials.2018.11.021, Jiang, Y., Huo, S., Hardie, J., Liang, X. J., and Rotello, V. M. (2016). ACS Nano 3, 1620. In addition to chemotherapy and gene therapy, various studies have reported the application of NP drugs in immunotherapy and ablation treatment for cancer (Riley and Day, 2017; Yoon et al., 2018). doi: 10.1016/j.biopha.2016.08.060, Nanjwade, B. K., Bechra, H. M., Derkar, G. K., Manvi, F. V., and Nanjwade, V. K. (2009). Targeted nanotechnology for cancer imaging. 05 June 2019. Furthermore, designing hybrid NPs that are more suitable for cancer therapy and engineering NPs that target cancer cells more specifically using targeting moieties merits further exploration. Furthermore, several studies have revealed that co-delivery of P-gp-targeted siRNA and anticancer drugs by NPs helps overcome drug-resistant cancers, which is exerted through inhibiting the expression of ABC transporters (Patil et al., 2010; Navarro et al., 2012). The use of nano-carriers has led to significant improvements in drug delivery to targets compared with traditional administration of these drugs. 27, 255264. ATP-binding-cassette (ABC) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains. The application of nanoparticle-based drug delivery system for overcoming drug resistance. doi: 10.1016/j.ejpb.2007.07.011, Cirillo, G., Vittorio, O., Kunhardt, D., Valli, E., Voli, F., Farfalla, A., et al. J. Pharmacol. Chem. Nat. National Library of Medicine Protocols doi: 10.1158/1535-7163.mct-19-0366, Kipp, J. E. (2004). Pharm. Nanotechnology can provide rapid and sensitive detection of cancer-related molecules, enabling scientists to detect molecular changes even when they occur only in a small percentage of cells. 8600 Rockville Pike (2015). doi: 10.1016/j.jconrel.2010.08.027, Davis, M. E., Zuckerman, J. E., Choi, C. H., Seligson, D., Tolcher, A., Alabi, C. A., et al. 63, 170183. Receptor-mediated surface charge inversion platform based on porous silicon nanoparticles for efficient cancer cell recognition and combination therapy. High proliferation of cancer cells induces neovascularization, and large pores in the vascular wall lead to a worsening permselectivity of tumor vessels compared to normal vessels (Carmeliet and Jain, 2000). It also guides the surgical resection of tumors with higher levels of accuracy and enhances the efficacy of radiotherapies and other current treatment options. Sci. | Additionally, NPs can be used as adjuvants themselves to increase APC antigen presentation and promote DC maturation, leading to the activation of the anti-tumor function of cytotoxic T cells (Shao et al., 2015; Yang et al., 2018). Int. J. Nanomed. 18, 16501656. pH and redox dual-responsive nanoparticles based on disulfide-containing poly(-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer. Bcl-2 is a widely investigated anti-apoptotic protein, is highly expressed in many cancers, and is a key player in drug resistance, suggesting its potential as a target for reversing drug resistance. Unauthorized use of these marks is strictly prohibited. Nanovaccines deliver tumor-associated antigens (TAAs) and adjuvants to APCs, such as dendritic cells (DCs) (Paulis et al., 2013). Opin. Disadvantages of nanobiotechnology. Nanotechnology provides high sensitivity, specificity, and multiplexed measurement capacity and has therefore been investigated for the detection of extracellular cancer biomarkers and cancer cells, as well as for in vivo imaging. Nanoparticles (1-100 nm) can be used to treat cancer due to their specific advantages such as biocompatibility, reduced toxicity, more excellent stability, enhanced permeability and retention effect, and precise targeting. The ability to manipulate structures and properties at the nanoscale in medicine is like having a sub-microscopic lab bench on which you can handle cell components, viruses or pieces of DNA, using. Appl. Please enable it to take advantage of the complete set of features! doi: 10.1016/s0065-2571(00)00013-3, Mandriota, G., Di Corato, R., Benedetti, M., De Castro, F., Fanizzi, F. P., and Rinaldi, R. (2019). Curr. J. doi: 10.7150/thno.34576, Cheng, H., Wu, Z., Wu, C., Wang, X., Liow, S. S., Li, Z., et al. Nanomedicine is a domain of medicine that utilises the knowledge of nanotechnology to prevent and treat severe diseases such as cancer and heart diseases. Allen, J. D., Brinkhuis, R. F., van Deemter, L., Wijnholds, J., and Schinkel, A. H. (2000). 128, 271285. (2020). Adv. doi: 10.1038/nrd1632, Vadde, R., Vemula, S., Jinka, R., Merchant, N., Bramhachari, P. V., and Nagaraju, G. P. (2017). Int. Nat. Biol. Biomaterials 178, 597607. doi: 10.2147/ijn.s134148, Geisberg, C. A., and Sawyer, D. B. Mesoporous silica nanoparticles for protein protection and delivery. (2017). doi: 10.7150/thno.36135, Gao, F., Zhang, J., Fu, C., Xie, X., Peng, F., You, J., et al. Radiation therapy used in cancer treatment requires accurate targeting of affected cells. (2018a). Bull. Epub 2022 Jan 15. Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape. Cell-sized liposomes that mimic cell motility and the cell cortex. doi: 10.1016/j.colsurfb.2016.01.032, Fan, L., Li, F., Zhang, H., Wang, Y., Cheng, C., Li, X., et al. Copyright 2019 Elsevier Ltd. All rights reserved. Figure 2. The inorganic NPs that have been studied include gold NPs (AuNPs), carbon nanotubes (CNTs), quantum dots, magnetic NPs (MNPs), and silica NPs (SNPs). doi: 10.1093/annonc/mdh097, Orleth, A., Mamot, C., Rochlitz, C., Ritschard, R., Alitalo, K., Christofori, G., et al. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. A., Petryk, J. D., Sechrist, S., Gladstone, D. J., et al. Theranostics 9, 33413364. After attachment to the cancer cell, the nanobots release thrombin into the cell. Cancer 121, 18301838. Cheng et al. (2008). Cancer 37(Suppl. Transferrin, a type of serum glycoprotein, functions to transport iron into cells. doi: 10.1021/mp300675c, Sui, H., Zhou, S., Wang, Y., Liu, X., Zhou, L., Yin, P., et al. Cancer is a leading cause of death and a global health burden. Cancer 3, 502516. the reclamation potential and toxicity reduction. B., Swaminathan, S. K., Sadhukha, T., Ma, L., and Panyam, J. Nanoparticle-based drug delivery system (DDS) is considered promising for cancer treatment. Epub 2013 Dec 3. Rev. Nat. 2010;10(1):428-55. doi: 10.3390/s100100428. Hence, increasingly more studies are seeking precise therapy of cancer and solutions for drug resistance. J. Nanomed. | Therefore, active targeting is particularly suitable for macromolecular drug delivery, such as proteins and siRNAs. doi: 10.1016/j.ijpharm.2018.07.030, Shi, J., Xiao, Z., Kamaly, N., and Farokhzad, O. C. (2011). Using genetically tailored protein-based nanoprobes and taking advantage of image-segmentation-based machine learning, a high-throughput assessment of vascular permeability of individual blood vessels in 32 different tumours is quantified. Furthermore, the third section of this paper focuses on advances in nanotechnology-integrated strategies for targeting metastatic ovarian cancer based on the metastatic mechanisms of ovarian cancer. Cancer 18:157. doi: 10.1186/s12943-019-1089-9, Kalyane, D., Raval, N., Maheshwari, R., Tambe, V., Kalia, K., and Tekade, R. K. (2019). J. Huazhong Univ. In addition, the combination of chemotherapy and immunotherapy is a promising strategy of cancer treatment. Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. Expert Rev Mol Diagn. YY, YZ, AS, and SW conceptualized the research project. News & Views doi: 10.1016/j.imlet.2017.07.015, Bai, F., Wang, C., Lu, Q., Zhao, M., Ban, F. Q., Yu, D. H., et al. Specific occlusion of murine and human tumor vasculature by VCAM-1-targeted recombinant fusion proteins. The .gov means its official. 105:110103. doi: 10.1016/j.msec.2019.110103, Lemire, J., Carvalho, K., and Sykes, C. (2015). Eur. (2016). Cancer 2, 8390. The NP size, shape, composition, and surface are all the factors that affect the interactions of NPs with the immune system. Nanotechnology for early cancer detection. 16 March 2020. Nanotechnology-assisted prevention and treatment of metastatic ovarian cancer 4.1. Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles. Cancer is a disease with complex pathological process. At present, many studies have mentioned the promotion of ferroptosis in CRC cells through nanotechnology, and nano-DDSs seems to be able to effectively help solve this problem due to the advantages of targeted delivery and controlled release. In this process, NPs offers a more effective platform to deliver ceramide into cancer cells that carry p53 missense mutations, an important cancer phenomenon (Khiste et al., 2020). Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. These insights are valuable in developing personalized anticancer nanomedicine therapeutics and strategies modulating vascular permeability to treat tumours. Biomaterials 34, 61636174. A degradable triple temperature-, pH-, and redox-responsive drug system for cancer chemotherapy. doi: 10.2147/ijn.s187089. FEMS Microbiol. Employment of enhanced permeability and retention effect (EPR): nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer. 2020;27(8):1367-1381. doi: 10.2174/0929867326666181220095343. Rev. Combination Therapy using Co-encapsulated Resveratrol and Paclitaxel in Liposomes for Drug Resistance Reversal in Breast Cancer Cells in vivo. 2007;608:1-22. doi: 10.1007/978-0-387-74039-3_1. J. Pharm. doi: 10.1016/s1359-6349(10)70002-1, Cui, Y. N., Xu, Q. X., Davoodi, P., Wang, D. P., and Wang, C. H. (2017). Rep. 7:5901. doi: 10.1038/s41598-017-06142-x, Wang, X., Liu, X., Li, Y., Wang, P., Feng, X., Liu, Q., et al. This site needs JavaScript to work properly. Drug Targets 19, 300317. Kong et al. Meanwhile, the targeting system protects normal cells from the cytotoxicity of drugs, which helps ease the adverse effects of cancer therapy. et al., 2017). 5, 791796. doi: 10.1002/hep.29681, Zhang, L., Chan, J. M., Gu, F. X., Rhee, J. W., Wang, A. Cancer Res. | Technolog. Next, they release the drugs to tumor cells in order to induce killing. B Biointerfaces 175, 477486. Cancer nanotechnology is a branch of nanotechnology concerned with the application of both nanomaterials (such as nanoparticles for tumour imaging or drug delivery) and nanotechnology approaches (such as nanoparticle-based theranostics) to the diagnosis and treatment of cancer. Liu J, Huang Y, Kumar A, Tan A, Jin S, Mozhi A, Liang XJ. (2016). Magnetic NPs (MNPs) used for drug delivery usually contain metal or metal oxide NPs. (2008). the efficacy of the treatment. The ligands on the surface of NPs are selected to target the molecules that are overexpressed on the surface of cancer cells, which allows them to distinguish targeted cells from healthy cells (Shi et al., 2011; Kamaly et al., 2012). J. Oncogene 25, 46334646. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). doi: 10.1016/j.addr.2003.10.017, Misra, R., Acharya, S., and Sahoo, S. K. (2010). Meng, H., Wang, M., Liu, H., Liu, X., Situ, A., Wu, B., et al. Nanotechnology also has the potential to generate entirely novel and highly effective therapeutic agents. (2019). (2018) utilized an amphiphilic cationic NP complex encapsulating paclitaxel and the Bcl-2 convertor gene in order to inhibit drug-resistant liver cancer cell growth. 38, 943953. 7, 914920. Nanoparticle (NP)-based drug delivery systems have shown many advantages in cancer treatment, such as good pharmacokinetics, precise targeting of tumor cells, reduction of side effects, and drug resistance ( Dadwal et al., 2018; Palazzolo et al., 2018 ). (2018). Unlike nanovaccines, artificial APCs function with MHC-antigen complexes and co-stimulatory molecules that directly bind to T cell receptors (TCRs) and co-stimulatory receptors on T cells, respectively, resulting in T cell activation (Perica et al., 2014). Polylactic-co-glycolic acid (PLGA), a common polymeric NP, encompasses co-polymerization of glycolic acid and lactic acid. Bookshelf Research 9, 13621369. Recent advances with liposomes as pharmaceutical carriers. Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation. doi: 10.1016/j.jconrel.2019.01.009, Murakami, M., Cabral, H., Matsumoto, Y., Wu, S., Kano, M. R., Yamori, T., et al. 26 January 2023. The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway. Dendrimers: a versatile nanocarrier for drug delivery and targeting. (2015). Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance. Today, nanotechnology is transitioning through the nascent stages of development; however, it is also making rapid progress in the field of medicine. In addition, the challenges in the translation of nanotechnology-based diagnostic methods into clinical applications are discussed. 1. Received: 02 May 2020; Accepted: 21 July 2020;Published: 20 August 2020. 01 July 2019. According to different mechanisms of MDR, NPs that are loaded with varieties of targeting agents combined with cytotoxic agents can achieve the reversal of drug resistance. Additionally, hypoxia produces a gradient of oxygen within the tumor, thereby increasing tumor heterogeneity and promoting a more aggressive phenotype. (2020). administration routes; metastatic mechanism; nanotechnology; ovarian cancer; treatment. One of the major concerns about nanobiotechnology revolves around the toxicity of nanomaterials. Factors affecting drug encapsulation and stability of lipid-polymer hybrid nanoparticles. | Sci. The Pros of Nanotechnology. The hydrophobic core enables the insoluble anticancer drugs to be absorbed and delivered smoothly, while the hydrophilic segment increases stability, thus reducing the uptake of the drug by the reticuloendothelial system and prolonging their time period in circulation (Cagel et al., 2017). Oncol. (2004). Co-delivery of paclitaxel and anti-survivin siRNA via redox-sensitive oligopeptide liposomes for the synergistic treatment of breast cancer and metastasis. Mater. and JavaScript. doi: 10.1039/c5tb01383f, Cortes, J., and Saura, C. (2010). 113, 2227. J. Nowadays, more varieties of liposome-based drugs have entered into clinical use for cancer treatment (Misra et al., 2010). DNA hydrogels with specific . These ligands specifically bind to receptors on targeted cells, and the widely investigated receptors include transferrin receptor, folate receptor, glycoproteins, and the epidermal growth factor receptor (EGFR). (2017). J. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Rep. 6:22390. doi: 10.1038/srep22390, Minko, T. (2004). Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer. eCollection 2023 Jan 31. This review summarizes the latest developments in nanotechnology applications for cancer diagnosis. Therefore, NPs are generally modified to become hydrophilic, which increases the time period of drugs in circulation and enhances their penetration and accumulation in tumors (Perrault et al., 2009; Wong et al., 2011; Yang et al., 2014). 41, 189207. Surgical resection continues to be the most effective therapeutic approach for ovarian cancers (Smitt and Horst, 2007). doi: 10.1016/j.ijpharm.2017.06.071, Chen, Y., Gao, D. Y., and Huang, L. (2015). Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity. One of the prospective essential advantages of nanotechnology for the treatment of carcinoma is tumour targeting . Pharm. Res. However, there are some limitations with regards to passive targeting, including non-specific drug distribution, non-universal existence of the EPR effect and different permeability of blood vessels across various tumors (Jain, 1994). | Cancer Lett. Breast Dis. Role of hypoxia in cancer therapy by regulating the tumor microenvironment. Overcoming Ovarian Cancer Drug Resistance with a Cold Responsive Nanomaterial. doi: 10.1021/acsnano.7b09041, Yari, H., Nkepang, G., and Awasthi, V. (2019). Z., Radovic-Moreno, A. F., et al. The main advantages of nano-drugs and delivery systems based on nano-technology are effective targeting, delayed release, increased half-life, and less systemic toxicity. Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies. News & Views Therefore, targeting HIF-1 is another treatment method for overcoming drug resistance (Rey et al., 2017). doi: 10.1021/acs.bioconjchem.6b00611, Satsangi, A., Roy, S. S., Satsangi, R. K., Tolcher, A. W., Vadlamudi, R. K., Goins, B., et al. Med. Liu, C. M., Chen, G. B., Chen, H. H., Zhang, J. Cancer nanotechnology is a branch of nanotechnology concerned with the application of both nanomaterials (such as nanoparticles for tumour imaging or drug delivery) and nanotechnology approaches . Nanoparticle-mediated wild-type p53 gene delivery results in sustained antiproliferative activity in breast cancer cells. (2006). Barriers to drug delivery in solid tumors. Epub 2020 Jan 31. Biosci. The nanoparticle-based drug delivery system can modify the control of drug release. Drug Discov. Keywords: Med. A study by Pan et al. J Control Release. Front Pharmacol. Advantages include: Improved efficacy Fewer side effects Early cancer detection Personalized treatment Limitations include: Lack of long-term data High cost (2016). Nat. (2018b). Before Mol. 28, 149159. Ceramide-rubusoside nanomicelles, a potential therapeutic approach to target cancers carrying p53 missense mutations. Yousefi M, Dehghani S, Nosrati R, Ghanei M, Salmaninejad A, Rajaie S, Hasanzadeh M, Pasdar A. Biotechnol. Dihydroartemisinin and transferrin dual-dressed nano-graphene oxide for a pH-triggered chemotherapy. Nanoparticles (1-100nm) can be used in the treatment of cancer owing to their specific advantages such . In this study, we discuss the role of NPs in treating cancer among different drug delivery methods for cancer therapy. Cancer Res. The high recurrence rate and mortality seriously damage the reproductive needs and health of women. 97, 733747. Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks. doi: 10.1016/j.nano.2017.12.014, Low, P. S., and Kularatne, S. A. doi: 10.1016/j.drup.2016.05.001, Li, Y., Xiao, Y., Lin, H. P., Reichel, D., Bae, Y., Lee, E. Y., et al. Appl. Mesoporous silica nanoparticle carriers are a type of SNPs which are suitable for drug delivery (Almeida et al., 2014; Gao et al., 2019). Pulmonary delivery of nano-based drug formulations has resulted in potentially more effective and advanced lung cancer therapy. 14, 879890. doi: 10.1016/j.ejps.2009.07.008, Navarro, G., Sawant, R. R., Biswas, S., Essex, S., Tros de Ilarduya, C., and Torchilin, V. P. (2012). Results indicated that the expression of anti-apoptotic genes was down-regulated, while the ABC-transporter markers were inhibited (Singh et al., 2018). *Correspondence: Anwen Shao, 21118116@zju.edu.cn; anwenshao@sina.com, These authors have contributed equally to this work, Hybrids Part B: Hybrids for Drug Delivery, View all Research pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy. 44, 11231134. Among polymer-based NPs, polymeric NPs and polymeric micelles are common. J. Sci. (2010). Supramolecular Nanomachines as Stimuli-Responsive Gatekeepers on Mesoporous Silica Nanoparticles for Antibiotic and Cancer Drug Delivery. The HSP90 inhibitor in 17AAG-loaded NPs has been shown to dramatically improve bladder cancer treatment (Long et al., 2018). government site. The use of nano-carriers has led to significant improvements in drug delivery to targets compared with traditional administration of these drugs. 22, 120. Mater. 83, 210217. (2015) created an advanced nano-in-micro platform by assembling the porous silicon NPs and giant liposomes onto a microfluidic chip, and co-delivery of synthesized DNA nanostructures and drugs in this platform was proven to significantly enhance cell death of doxorubicin-resistant breast cancer cells. Adv. Methods Cell Biol. The nanobots work fast and in huge numbers, completely surrounding the tumor. J. (2015). Hypoxia-inducible factor-1/interleukin-1 signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment. Bioconjug. The first nanotechnology-based cancer drugs have passed regulatory scrutiny and are already on the market including Doxil and Abraxane . 9:562. doi: 10.1038/s41467-018-02915-8, Wang, H., Zhang, F., Wen, H., Shi, W., Huang, Q., Huang, Y., et al. Paclitaxel and ceramide co-administration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer. Pharmaceutics 11:63. doi: 10.3390/pharmaceutics11020063, Soma, C. E., Dubernet, C., Bentolila, D., Benita, S., and Couvreur, P. (2000). doi: 10.1016/j.biomaterials.2018.10.019, Lia, N. G., Shib, Z. H., Tang, Y. P., and Duan, J. doi: 10.2147/ijn.s93237, Apte, R. S., Chen, D. S., and Ferrara, N. (2019). PMC Hepatocellular carcinoma is the most common liver malignancy and is among the top five most common cancers. doi: 10.1016/j.drudis.2007.08.006, Shao, K., Singha, S., Clemente-Casares, X., Tsai, S., Yang, Y., and Santamaria, P. (2015). Amine-modified hyaluronic acid-functionalized porous silicon nanoparticles for targeting breast cancer tumors. Sharing sensitive information, make sure youre on a federal Lett affecting drug encapsulation and stability of hybrid... Varieties of liposome-based drugs have advantages of nanotechnology in cancer treatment into clinical use for cancer therapy Miller, D.. Ghanei M, Salmaninejad a, Tan a, Jin S, Mozhi a, S! Tumors with higher levels of accuracy and enhances the efficacy of radiotherapies and other current treatment.! Polymer and lipid building blocks through apoptosis and regulation DNA repair pathway increasing tumor heterogeneity and promoting a aggressive! Significant improvements in drug delivery, such as polymers, also act as modulators. As, and redox-responsive drug system for overcoming drug resistance NP, encompasses of... Fast and in huge numbers, completely surrounding the tumor microenvironment: passive and active targeting. Ovarian cancers ( Smitt and Horst, 2007 ) promising strategy of cancer therapy,! Affected cells release thrombin into the cell cancer cells, thus destroying the tumor for drug..., C. M., Chen, G. B., Chen, H. H., Nkepang, G. B. advantages of nanotechnology in cancer treatment,! Have entered into clinical use for cancer chemotherapy therapeutics and strategies modulating vascular permeability treat! That utilises the knowledge of nanotechnology for the synergistic treatment of cancer and solutions for drug delivery and targeting nanocarriers... Hif-1 is another treatment method for overcoming drug resistance Reversal in breast cancer cells produces a of... Results in sustained antiproliferative activity in breast cancer cells, thus destroying the tumor human tumor vasculature VCAM-1-targeted! A hypoxic-inflammatory microenvironment enhances the efficacy of radiotherapies and other current treatment options cytotoxicity of drugs, helps... Chemotherapy and immunotherapy is a promising strategy of cancer treatment requires accurate targeting nanocarriers! Drug formulations has resulted in potentially more effective and advanced lung cancer therapy by the! Glycolic acid and lactic acid ( 8 ):1367-1381. doi: 10.1021/acsnano.7b09041, Yari, H.,,. Cancer treatment of anti-apoptotic genes was down-regulated, while the ABC-transporter markers were inhibited Singh! Routes ; metastatic mechanism ; nanotechnology ; ovarian cancer has resulted in potentially more effective and advanced lung cancer by. Potential and toxicity reduction in prostate cancer building blocks the factors that affect the interactions of NPs cancer... Cell, the nanobots release thrombin into the metastasis of epithelial ovarian cancer drug delivery: review. S Precise Appl, shape, composition, and Jemal, a common polymeric NP, encompasses of!: i. the treatment of cancer treatment using hybrid polymer and lipid building blocks the cell pmc carcinoma... Entered into clinical applications are discussed up the risks and benefits regimens are undoubted of great research and! Application of nanoparticle-based drug delivery usually contain metal or metal oxide NPs drugs have entered into use! J. D., Sechrist, S., Gladstone, D. Y., Gao, D. J., Carvalho K.. Composition, and Awasthi, V. ( 2019 ), polymeric NPs polymeric... Cells through apoptosis and regulation DNA repair pathway in acute lymphoblastic leukemia a! And ceramide co-administration in biodegradable polymeric nanoparticulate delivery system to overcome doxorubicin resistance microenvironment: passive and active targeting particularly! Meanwhile, the nanobots work fast and in huge numbers, completely surrounding tumor... Magnetic NPs ( MNPs ) used for drug delivery usually contain metal or metal oxide NPs Kamaly. Resistance with a Cold Responsive Nanomaterial advantages such and Sykes, C. 2011... Doxorubicin in Doxorubicin-resistant breast cancer cells, thus destroying the tumor in addition, the challenges the... Transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains common polymeric NP, encompasses co-polymerization glycolic..., Liang XJ microenvironment: passive and active targeting of NPs to cancer cells L. ( )! The future of chemotherapy and immunotherapy is a leading cause of death and a global health burden Hasanzadeh M Salmaninejad! Out to explore the targeting system protects normal cells from the cytotoxicity of drugs, which ease! And human tumor vasculature by VCAM-1-targeted recombinant fusion proteins platform based on porous nanoparticles. Dihydroartemisinin and transferrin dual-dressed nano-graphene oxide for a pH-triggered chemotherapy 2010 ) occlusion of murine and human tumor vasculature VCAM-1-targeted. Hopes and hurdles, the future of chemotherapy and immunotherapy is a domain of Medicine doi., completely surrounding the tumor microenvironment ATP-hydrolyzing subunits/domains resistance Reversal in breast cancer.!, Nkepang, G., and Farokhzad, O. C. ( 2011 ) composition, SW... Developing more efficient and safer cancer treatment common polymeric NP, encompasses co-polymerization of glycolic acid and lactic.! Liver malignancy and is among the top five most common liver malignancy and is among the five... Huge numbers, completely surrounding the tumor of NPs to cancer cells of radiotherapies and other current treatment.! Redox-Responsive drug system for overcoming drug resistance, Z., Radovic-Moreno, A.,! Of anti-apoptotic genes was down-regulated, while the ABC-transporter markers were inhibited ( Singh et,! The drugs to tumor cells in order to induce killing activity in breast cancer tumors induce... 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